Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection.

  title={Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection.},
  author={Min Fang and Nicholas A. Siciliano and Adam R. Hersperger and Felicia Roscoe and Angela Youxin Hu and Xueying Ma and Ahamed R Shamsedeen and Laurence Eisenlohr and Luis J Sigal},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 25},
CD4(+) T cells are generally regarded as helpers and regulators of the immune response. Although cytolytic CD4(+) T cells have been described, whether those generated during the course of a viral infection play a role in virus control remains unknown. Here we show that during acute infection with ectromelia virus, the mouse homolog of the human virus of smallpox, large numbers of CD4(+) T cells in the draining lymph node and liver of resistant mice have a cytotoxic phenotype. We also show that… CONTINUE READING


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