Perforin and granzymes: function, dysfunction and human pathology

  title={Perforin and granzymes: function, dysfunction and human pathology},
  author={Ilia Voskoboinik and James C. Whisstock and Joseph A. Trapani},
  journal={Nature Reviews Immunology},
A defining property of cytotoxic lymphocytes is their expression and regulated secretion of potent toxins, including the pore-forming protein perforin and serine protease granzymes. Until recently, mechanisms of pore formation and granzyme transfer into the target cell were poorly understood, but advances in structural and cellular biology have now begun to unravel how synergy between perforin and granzymes brings about target cell death. These and other advances are demonstrating the… CONTINUE READING
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