Perforin: a key pore-forming protein for immune control of viruses and cancer.

Abstract

Perforin (PFN) is the key pore-forming molecule in the cytotoxic granules of immune killer cells. Expressed only in killer cells, PFN is the rate-limiting molecule for cytotoxic function, delivering the death-inducing granule serine proteases (granzymes) into target cells marked for immune elimination. In this chapter we describe our current understanding… (More)
DOI: 10.1007/978-94-017-8881-6_10

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