Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells.

@article{Lee1996PerforinFL,
  title={Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells.},
  author={Richard Lee and Julie Spielman and Daniel Y Zhao and Kristin J. Olsen and Eckhard R. Podack},
  journal={Journal of immunology},
  year={1996},
  volume={157 5},
  pages={1919-25}
}
Lymphokine-activated killer (LAK) cells generated from perforin knockout mice possess significantly reduced cytotoxicity against a panel of tumor target cell lines, with some tumor cells being lysed exclusively by the perforin pathway. LAK cells are also capable of Fas ligand-mediated cytotoxicity. LAK cells generated from mice deficient in both perforin and Fas ligand (PKO/gld) were not cytolytic in short term cytotoxicity assays, demonstrating that perforin and Fas ligand are required for… CONTINUE READING

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