Perforation of toxic megacolon in non-typhoid Salmonella enterocolitis spares young infants and is immune-mediated

@article{Chiu2002PerforationOT,
  title={Perforation of toxic megacolon in non-typhoid Salmonella enterocolitis spares young infants and is immune-mediated},
  author={C.-H. Chiu and L.-H. Su and C.-C. He and T.-H. Jaing and C. Luo and T.-Y. Lin},
  journal={Pediatric Surgery International},
  year={2002},
  volume={18},
  pages={410-412}
}
Intestinal perforation, a life-threatening complication of toxic megacolon (TM) following non-typhoid Salmonella infection, is relatively uncommon in infants less than 1 year of age. The situation, also found in typhoid fever, appears to be cytokine-mediated. This finding may justify immunotherapy for older children with TM associated with non-typhoid Salmonella infection in order to prevent this complication. 

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