Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha.

@article{Abbott2007PerfluorooctanoicAI,
  title={Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha.},
  author={Barbara Abbott and Cynthia J. Wolf and Judith E. Schmid and Kaberi P. Das and Robert D. Zehr and Laurence J Helfant and Shoji F. Nakayama and Andrew B. Lindstrom and Mark Strynar and Christopher D. Lau},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2007},
  volume={98 2},
  pages={571-81}
}
Perfluorooctanoic acid (PFOA) is a member of a family of perfluorinated chemicals that have a variety of applications. PFOA persists in the environment and is found in wildlife and humans. In mice, PFOA is developmentally toxic producing mortality, delayed eye opening, growth deficits, and altered pubertal maturation. PFOA activates peroxisome proliferators… CONTINUE READING