Perfluorooctanoic Acid–Induced Immunomodulation in Adult C57BL/6J or C57BL/6N Female Mice

@inproceedings{Dewitt2008PerfluorooctanoicAI,
  title={Perfluorooctanoic Acid–Induced Immunomodulation in Adult C57BL/6J or C57BL/6N Female Mice},
  author={Jamie C. Dewitt and Carey B. Copeland and Mark Strynar and Robert L{\"u}bke},
  booktitle={Environmental health perspectives},
  year={2008}
}
BACKGROUND Perfluorooctanoic acid (PFOA), an environmentally persistent compound of regulatory concern, has been reported to reduce antibody responses in mice at a single dose. OBJECTIVE The aim of this study was to evaluate PFOA effects on humoral and cellular immunity using standard assays for assessing immune function, and to derive dose-response data. METHODS C57BL/6J mice received 0 or 30 mg PFOA/kg/day for 10 days; half of the exposed groups were switched to vehicle and half continued… CONTINUE READING
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