Percutaneously absorbed NSAIDs attenuate local production of proinflammatory cytokines and suppress the expression of c-Fos in the spinal cord of a rodent model of knee osteoarthritis.

@article{Orita2012PercutaneouslyAN,
  title={Percutaneously absorbed NSAIDs attenuate local production of proinflammatory cytokines and suppress the expression of c-Fos in the spinal cord of a rodent model of knee osteoarthritis.},
  author={Sumihisa Orita and Tetsuhiro Ishikawa and Masayuki Miyagi and Nobuyasu Ochiai and Gen Inoue and Yawara Eguchi and Hiroto Kamoda and Gen Arai and Miyako Suzuki and Yoshihiro Sakuma and Yasuhiro Oikawa and Tomoaki Toyone and Yasuchika Aoki and Kazuhisa Takahashi and Seiji Ohtori},
  journal={Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association},
  year={2012},
  volume={17 1},
  pages={77-86}
}
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical situations to reduce inflammation and pain. Percutaneous administration is one of the routes mainly used in Japan to deal with the pain from acute injuries, to chronic pain such as chronic low back pain and osteoarthritis (OA). There have been no studies that report the effect of percutaneous administration of NSAIDs on chronic pain in animal models. This study aimed to investigate the effect of… CONTINUE READING
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