Percutaneous penetration of local anesthetic bases: pharmacodynamic measurements.

  title={Percutaneous penetration of local anesthetic bases: pharmacodynamic measurements.},
  author={Claudia Sabine Leopold and Howard Ira Maibach},
  journal={The Journal of investigative dermatology},
  volume={113 3},
Local anesthetics do not penetrate readily through human skin if applied in their salt form; however, if applied in their base form various effects may be observed, such as a decrease in pricking pain and a change in burning, itch, and thermal sensations. These effects occur after skin penetration and may be attributed to the action of the anesthetics on nociceptors and thermoreceptors, i.e., on C and Adelta nerve fiber respectively. As there is little known about the time course of the… CONTINUE READING

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