Percutaneous penetration and skin retention of topically applied compounds: an in vitro-in vivo study.

@article{Reifenrath1991PercutaneousPA,
  title={Percutaneous penetration and skin retention of topically applied compounds: an in vitro-in vivo study.},
  author={William G. Reifenrath and G S Hawkins and Meester Kurtz},
  journal={Journal of pharmaceutical sciences},
  year={1991},
  volume={80 6},
  pages={526-32}
}
Radiolabeled compounds with varying partition coefficients (paraoxon, benzoic acid, parathion, and DDT) were chosen to study the percutaneous penetration and extent of dermal retention in pig skin both in vitro and in vivo. Radiolabel distributions within the skin were determined from 1 min to 24 h after application in ethanol. The distribution of radioactivity in the skin during the first 4 h was comparable between in vitro and in vivo experiments. At 24 h, radioactive residues in the dermis… CONTINUE READING

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