Percutaneous adenoviral gene transfer into porcine coronary arteries: is catheter-based gene delivery adapted to coronary circulation?

@article{Varenne1999PercutaneousAG,
  title={Percutaneous adenoviral gene transfer into porcine coronary arteries: is catheter-based gene delivery adapted to coronary circulation?},
  author={Olivier Varenne and Robert D. Gerard and Peter R. Sinnaeve and Hilde Gillijns and D{\'e}sir{\'e} Collen and Stefan P. Janssens},
  journal={Human gene therapy},
  year={1999},
  volume={10 7},
  pages={1105-15}
}
Recombinant adenoviral (Ad) vectors represent an efficient gene transfer system for targeting the cardiovascular system. Phenotypic modulation of coronary vascular cells in vivo is, however, critically dependent on the efficacy of local delivery devices. Four local drug delivery catheters were tested for intracoronary gene transfer efficiency: the Infiltrator (INF, n = 10), the Crescendo (CRE, n = 10), the Infusasleeve (SLE, n = 8), and the Remedy balloon (channel balloon [CHA], n = 8). After… CONTINUE READING