Percutaneous absorption of diclofenac in healthy volunteers after single and repeated topical application of diclofenac Emulgel.

Abstract

The percutaneous absorption of diclofenac was studied in ten healthy volunteers treated with Emulgel containing 1.16% diclofenac diethylammonium for 8 d as follows: a single application of 5 g Emulgel on days 1 and 8, and two applications d-1 on days 2-7. Plasma concentration profiles of unchanged diclofenac and urinary concentrations of total diclofenac… (More)

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@article{Sioufi1994PercutaneousAO, title={Percutaneous absorption of diclofenac in healthy volunteers after single and repeated topical application of diclofenac Emulgel.}, author={Antoine Sioufi and Françoise Pommier and Fr{\'e}d{\'e}ric Boschet and Jacques A. Godbillon and D Lavoignat and D. Salliere}, journal={Biopharmaceutics & drug disposition}, year={1994}, volume={15 6}, pages={441-9} }