Percutaneous absorption of alkanoic acids II: Application of regular solution theory.

  title={Percutaneous absorption of alkanoic acids II: Application of regular solution theory.},
  author={Z Liron and Seth Cohen},
  journal={Journal of pharmaceutical sciences},
  volume={73 4},
The permeability coefficient, Kp, of pure unbranched alkanoic acids (C2-C7) applied to isolated porcine skin, reached a maximum in the solubility parameter (delta 2) range of 9.7-10 cal1 /2/cm3/2. When these and other penetrants were delivered from a solvent vehicle, the following linear relationships could be demonstrated: (a) between log Kp and the molar attraction constant of the penetrant [delta 2v2 or (-Ev)1/2] for six unbranched and six branched acids delivered from 1 M solution in n… CONTINUE READING

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