Percutaneous absorption and routes of excretion of ditophal (Etisul)

@article{Ellard1963PercutaneousAA,
  title={Percutaneous absorption and routes of excretion of ditophal (Etisul)},
  author={G. A. Ellard and J. Garrod and B. Scales and G. Snow},
  journal={Biochemical Pharmacology},
  year={1963},
  volume={12},
  pages={271-281}
}
Abstract When 35 S-labelled ditophal is rubbed into the skin about 90 per cent of the drug is absorbed in 1 hr. Excretion of 35 S occurs in urine, faeces and sweat and less so in breath. The greatest rate of excretion is at 6–24 hr after inunction, but excretion continues for several weeks. The principal forms of excretion are toluene-extractable material and sulphate. 
2 Citations
DISTRIBUTION, METABOLISM AND EXCRETION OF PERCUTANEOUSLY ADMINISTERED DITOPHAL ("ETISUL").
Abstract When 35 S-labelled ditophal is rubbed into the skin it is rapidly distributed throughout the body via the circulating blood and radioactivity is concentrated in the skin, both at the site ofExpand
Routes of Administration and Drug Response
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The route of administration for a drug should be selected to achieve an effective concentration at the site of action as conveniently as possible and to ensure rapidity of onset and duration of drug effect. Expand

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