Perceptions of epigenetics
@article{Bird2007PerceptionsOE, title={Perceptions of epigenetics}, author={Adrian Bird}, journal={Nature}, year={2007}, volume={447}, pages={396-398} }
Geneticists study the gene; however, for epigeneticists, there is no obvious 'epigene'. Nevertheless, during the past year, more than 2,500 articles, numerous scientific meetings and a new journal were devoted to the subject of epigenetics. It encompasses some of the most exciting contemporary biology and is portrayed by the popular press as a revolutionary new science — an antidote to the idea that we are hard-wired by our genes. So what is epigenetics?
2,500 Citations
Epigenetics: from the past to the present
- Biology
- 2016
The epigenome, as the bridge between the genome and the phenotype, is one of the most interesting current ideas in genetics and is so revolutionary that it may change present notions about inheritance and evolution.
The implications of environmental epigenetics
- Biology
- 2013
Findings in epigenetics suggest that the environment is a biochemically active inducer of phenotypical development and understandings of the delayed temporality and intergenerational effects of epigenetic mechanisms challenge methodologies that privilege space.
Transgenerational epigenetic inheritance: more questions than answers.
- BiologyGenome research
- 2010
These findings suggest that an environmental event in one generation could affect the phenotype in subsequent generations, and these somewhat Lamarckian ideas are stimulating interest from a broad spectrum of biologists, from ecologists to health workers.
Epigenetics in comparative physiology
- BiologyJournal of Experimental Biology
- 2015
Since the earliest definition of the term ‘epigenetics’ in 1942, the understanding of the concept has been refined extensively and the mechanism by which genes give rise to the phenotype during development has been clarified.
Systems biology and epigenetic gene regulation.
- BiologyIET systems biology
- 2010
This review concludes that the future expansion of epigenomics to cover multiple samples will offer an even more profound opportunity for systems biology research.
Advances in epigenetics link genetics to the environment and disease
- BiologyNature
- 2019
The authors review recent advances and current debates in epigenetics, including how epigenetic mechanisms interact with genetic variation, ageing, disease and the environment.
Epigenetics: The origins and evolution of a fashionable topic.
- BiologyDevelopmental biology
- 2016
What Do You Mean, “Epigenetic”?
- BiologyGenetics
- 2015
The history behind the multitude of definitions that have been employed since the conception of epigenetics are discussed, the components of these definitions are analyzed, and solutions for clarifying the field and mitigating the problems that have arisen due to these definitional ambiguities are offered.
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Older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait, indicating how an appreciation of epigenetics is missing from the understanding of how different phenotypes can be originated from the same genotype.