Percentage of Philadelphia chromosome (Ph)-negative and Ph-positive cells found after autologous transplantation for chronic myelogenous leukemia depends on percentage of diploid cells induced by conventional-dose chemotherapy before collection of autologous cells.

@article{Talpaz1995PercentageOP,
  title={Percentage of Philadelphia chromosome (Ph)-negative and Ph-positive cells found after autologous transplantation for chronic myelogenous leukemia depends on percentage of diploid cells induced by conventional-dose chemotherapy before collection of autologous cells.},
  author={Moshe Talpaz and Hagop A Kantarjian and Jing Liang and Leslie R Calvert and Julia Hamer and Paul Tibbits and April G. Durett and David F. Claxton and Sergio Giralt and Issa F. Khouri},
  journal={Blood},
  year={1995},
  volume={85 11},
  pages={3257-63}
}
We collected peripheral blood mononuclear cells and bone marrow cells soon after recovery from conventional-dose chemotherapy-induced myelosuppression and transplanted these cells into advanced chronic myelogenous leukemia (CML) patients after treating these patients with 120 mg/kg cyclophosphamide, 750 mg/m2 VP-16, and 1,020 cGy of total body irradiation (TBI). Of the 10 late chronic-phase patients and the eight accelerated-phase CML patients evaluable posttransplant, 90% and 87%, respectively… CONTINUE READING