Perazine, chlorpromazine and imipramine as inducers of microsomal drug metabolism

@article{Breyer1972PerazineCA,
  title={Perazine, chlorpromazine and imipramine as inducers of microsomal drug metabolism},
  author={Ursula Breyer},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1972},
  volume={272},
  pages={277-288}
}
  • Ursula Breyer
  • Published in
    Naunyn-Schmiedeberg's…
    1972
  • Chemistry, Medicine
  • SummaryMale rats were treated orally for 7 days with perazine, chlorpromazine, imipramine or phenobarbital. Isolated liver microsomes were tested for their metabolic activities towards perazine, ethylmorphine and aniline. N-Demethylation of perazine and ethylmorphine was increased 2–3.5 fold by all pretreatments. Aromatic hydroxylation of perazine was decreased in microsomes from pretreated animals, whereas aniline hydroxylation was enhanced even more by perazine and imipramine than by… CONTINUE READING

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