Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons

  title={Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons},
  author={Chao‐Yin Chen and Lucas Matt and Johannes W. Hell and Michael A. Rogawski},
  journal={PLoS ONE},
Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized. Here the action of perampanel on AMPA receptors was investigated by whole-cell voltage-clamp recording in cultured rat hippocampal neurons. Perampanel caused a slow (τ∼1 s at 3 µM), concentration-dependent inhibition of AMPA receptor currents evoked by AMPA and kainate… 

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