Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice.

@article{Chiou2012Peracetylated,
  title={Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice.},
  author={Yi-Shiou Chiou and Nianhan Jia-Lin Ma and Shengmin Sang and Chitang Ho and Ying-Jan Wang and Min-Hsiung Pan},
  journal={Journal of agricultural and food chemistry},
  year={2012},
  volume={60 13},
  pages={3441-51}
}
Previous studies reported that peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) has antiproliferative and anti-inflammatory activities. Here, we evaluated the chemopreventive effects and underlying molecular mechanisms of dietary administration of AcEGCG and EGCG in dextran sulfate sodium (DSS)-induced colitis in mice. The mice were fed a diet supplemented with either AcEGCG or EGCG prior to DSS induction. Our results indicated that AcEGCG administration was more effective than EGCG in… CONTINUE READING