Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion

@inproceedings{Xavier2010PerarntsimD,
  title={Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion},
  author={Gabriela Da Silva Xavier and Hesso Farhan and Hokwon Kim and Sara Caxaria and Paul R. V. Johnson and Stephen Hughes and Marco Bugliani and Lorella Marselli and Paola Marchetti and Fabian Birzele and Gao Sun and Rapha{\"e}l Scharfmann and Jared Rutter and Karolina Siniakowicz and Gordon C Weir and Helen E. Parker and Frank Reimann and Fiona M Gribble and Guy A Rutter},
  booktitle={Diabetologia},
  year={2010}
}
We assessed whether per-arnt-sim (PAS) domain-containing protein kinase (PASK) is involved in the regulation of glucagon secretion. mRNA levels were measured in islets by quantitative PCR and in pancreatic beta cells obtained by laser capture microdissection. Glucose tolerance, plasma hormone levels and islet hormone secretion were analysed in C57BL/6 Pask homozygote knockout mice (Pask −/−) and control littermates. Alpha-TC1-9 cells, human islets or cultured E13.5 rat pancreatic epithelia were… CONTINUE READING

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