Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis.

  title={Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis.},
  author={Shu De Wang and Yanming Wang},
  journal={Biochimica et biophysica acta},
  volume={1829 10},
Peptidylarginine deiminases are a family of enzymes that mediate post-translational modifications of protein arginine residues by deimination or demethylimination to produce citrulline. In vitro, the activity of PADs is dependent on calcium and reductive reagents carrying a free sulfhydryl group. The discovery that PAD4 can target both arginine and methyl-arginine for citrullination about 10years ago renewed our interest in studying this family of enzymes in gene regulation and their… CONTINUE READING


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