Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system.

@article{Musse2008PeptidylarginineD2,
  title={Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system.},
  author={Abdiwahab A. Musse and Zhen Li and Cameron A. Ackerley and Dorothee Bienzle and Helena Lei and Roberto Poma and George Harauz and Mario A. Moscarello and Fabrizio G. Mastronardi},
  journal={Disease models & mechanisms},
  year={2008},
  volume={1 4-5},
  pages={229-40}
}
Demyelination in the central nervous system is the hallmark feature in multiple sclerosis (MS). The mechanism resulting in destabilization of myelin is a complex multi-faceted process, part of which involves deimination of myelin basic protein (MBP). Deimination, the conversion of protein-bound arginine to citrulline, is mediated by the peptidylarginine deiminase (PAD) family of enzymes, of which the PAD2 and PAD4 isoforms are present in myelin. To test the hypothesis that PAD contributes to… CONTINUE READING

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Deimination of membrane-bound myelin basic protein in multiple sclerosis exposes an immunodominant epitope.

Proceedings of the National Academy of Sciences of the United States of America • 2006
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