Peptidyl-Prolyl Isomerase FKBP52 Controls Chemotropic Guidance of Neuronal Growth Cones via Regulation of TRPC1 Channel Opening

@article{Shim2009PeptidylProlylIF,
  title={Peptidyl-Prolyl Isomerase FKBP52 Controls Chemotropic Guidance of Neuronal Growth Cones via Regulation of TRPC1 Channel Opening},
  author={Sangwoo Shim and Joseph P. Yuan and Ju Young Kim and Weizhong Zeng and Guo Huang and Aleksandr Milshteyn and Dorothee Kern and Shmuel Muallem and Guoli Ming and Paul F Worley},
  journal={Neuron},
  year={2009},
  volume={64},
  pages={471-483}
}
Immunophilins, including FK506-binding proteins (FKBPs), are protein chaperones with peptidyl-prolyl isomerase (PPIase) activity. Initially identified as pharmacological receptors for immunosuppressants to regulate immune responses via isomerase-independent mechanisms, FKBPs are most highly expressed in the nervous system, where their physiological function as isomerases remains unknown. We demonstrate that FKBP12 and FKBP52 catalyze cis/trans isomerization of regions of TRPC1 implicated in… CONTINUE READING

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