Peptidomimics of antigen are present in variable region of heavy and light chains of anti-idiotypic antibody and function as surrogate antigen for perpetuation of immunological memory.

@article{Vani2007PeptidomimicsOA,
  title={Peptidomimics of antigen are present in variable region of heavy and light chains of anti-idiotypic antibody and function as surrogate antigen for perpetuation of immunological memory.},
  author={Janakiraman Vani and Jayakani Justin and R Chandra Nagasuma and Rabindranath Nayak and Melkote Subbarao Shaila},
  journal={Molecular immunology},
  year={2007},
  volume={44 13},
  pages={3345-54}
}
Peptide antigens composed of relevant B cell and T cell epitopes, capable of inducing protective immune response against the whole pathogen, are potentially safe, alternative vaccine antigens for prevention of wide range of diseases. Here, we show that short peptides derived from internal image sequences of anti-idiotypic antibody (peptidomimics) can function as both B and T cell epitopes and perpetuate antigen specific immunological memory. We have sequenced the variable regions of heavy and… CONTINUE READING
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