Peptidomimetic inhibitors of the human cytomegalovirus protease.

Abstract

The development of peptidomimetic inhibitors of the human cytomegalovirus (HCMV) protease showing sub-micromolar potency in an enzymatic assay is described. Selective substitution of the amino acid residues of these inhibitors led to the identification of tripeptide inhibitors showing improvements in inhibitor potency of 27-fold relative to inhibitor 39… (More)

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@article{Ogilvie1997PeptidomimeticIO, title={Peptidomimetic inhibitors of the human cytomegalovirus protease.}, author={William W Ogilvie and M Bailey and M A Poupart and Anup Abraham and Ankita S. Bhavsar and Pierre R Bonneau and Jos{\'e}e Bordeleau and Yves Bousquet and Christine Chabot and J S Duceppe and Gulrez Fazal and Sylvie Goulet and Chantal Grand-Ma{\^i}tre and Ingrid Guse and Teddy Halmos and Pierre Lavall{\'e}e and M Leach and Eric Malenfant and Jeff O'meara and Robert J. Plante and C{\'e}line Plouffe and Martin Poirier and François Soucy and Christiane Yoakim and Robert D{\'e}ziel}, journal={Journal of medicinal chemistry}, year={1997}, volume={40 25}, pages={4113-35} }