Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.

@article{Jiang2017PeptidomimeticIO,
  title={Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.},
  author={Haiming Jiang and R. Q. Deng and Xiuyan Yang and Jialin Shang and Shaoyong Lu and Yanlong Zhao and Kun Song and Xinyi Liu and Qiufen Zhang and Yu Chen and Y. Eugene Chinn and Geng Wu and Jian Li and Guoqiang Jerry Chen and Jianxiu Yu and Jian Zhang},
  journal={Nature chemical biology},
  year={2017},
  volume={13 9},
  pages={994-1001}
}
The binding of adenomatous polyposis coli (APC) to its receptor Asef relieves the negative intramolecular regulation of Asef and leads to aberrant cell migration in human colorectal cancer. Because of its crucial role in metastatic dissemination, the interaction between APC and Asef is an attractive target for anti-colorectal-cancer therapy. We rationally… CONTINUE READING