Peptidomic analysis of the neurolysin-knockout mouse brain.

  title={Peptidomic analysis of the neurolysin-knockout mouse brain.},
  author={Leandro M. Castro and Diogo M L P Cavalcanti and Christiane Bezerra Araujo and Vanessa Rioli and Marcelo Yudi Icimoto and Fabio Cesar Gozzo and Maria Aparecida Juliano and Luiz Juliano and Vitor Dornela de Oliveira and Emer Suavinho Ferro},
  journal={Journal of proteomics},
UNLABELLED A large number of intracellular peptides are constantly produced following protein degradation by the proteasome. A few of these peptides function in cell signaling and regulate protein-protein interactions. Neurolysin (Nln) is a structurally defined and biochemically well-characterized endooligopeptidase, and its subcellular distribution and biological activity in the vertebrate brain have been previously investigated. However, the contribution of Nln to peptide metabolism in vivo… CONTINUE READING
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