Peptidoglycan synthesis in the absence of class A penicillin-binding proteins in Bacillus subtilis.

@article{McPherson2003PeptidoglycanSI,
  title={Peptidoglycan synthesis in the absence of class A penicillin-binding proteins in Bacillus subtilis.},
  author={Derrell C. McPherson and David L Popham},
  journal={Journal of bacteriology},
  year={2003},
  volume={185 4},
  pages={1423-31}
}
Penicillin-binding proteins (PBPs) catalyze the final, essential reactions of peptidoglycan synthesis. Three classes of PBPs catalyze either trans-, endo-, or carboxypeptidase activities on the peptidoglycan peptide side chains. Only the class A high-molecular-weight PBPs have clearly demonstrated glycosyltransferase activities that polymerize the glycan strands, and in some species these proteins have been shown to be essential. The Bacillus subtilis genome sequence contains four genes… CONTINUE READING