Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis.

  title={Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis.},
  author={Christopher B. Hergott and Aoife M. Roche and Edwin Tamashiro and Thomas B. Clarke and Aubrey Bailey and Alice L. Laughlin and Frederic D. Bushman and Jeffrey N Weiser},
  volume={127 20},
Maintenance of myeloid cell homeostasis requires continuous turnover of phagocytes from the bloodstream, yet whether environmental signals influence phagocyte longevity in the absence of inflammation remains unknown. Here, we show that the gut microbiota regulates the steady-state cellular lifespan of neutrophils and inflammatory monocytes, the 2 most abundant circulating myeloid cells and key contributors to inflammatory responses. Treatment of mice with broad-spectrum antibiotics, or with the… CONTINUE READING
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