Peptidoglycan and Lipoteichoic Acid in Gram-Positive Bacterial Sepsis: Receptors, Signal Transduction, Biological Effects, and Synergism

@article{Wang2003PeptidoglycanAL,
  title={Peptidoglycan and Lipoteichoic Acid in Gram-Positive Bacterial Sepsis: Receptors, Signal Transduction, Biological Effects, and Synergism},
  author={Jacob E. Wang and Maria Krudtaa Dahle and Michelle Craig McDonald and Simon J. Foster and Ansgar Oddne Aasen and Christoph Thiemermann},
  journal={Shock},
  year={2003},
  volume={20},
  pages={402-414}
}
In sepsis and multiple organ dysfunction syndrome (MODS) caused by gram-negative bacteria, lipopolysaccharide (LPS) initiates the early signaling events leading to the deleterious inflammatory response. However, it has become clear that LPS can not reproduce all of the clinical features of sepsis, which emphasize the roles of other contributing factors. Gram-positive bacteria, which lack LPS, are today responsible for a substantial part of the incidents of sepsis with MODS. The major wall… 

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