Peptidoglycan N-acetylglucosamine deacetylation decreases autolysis in Lactococcus lactis.

@article{Meyrand2007PeptidoglycanND,
  title={Peptidoglycan N-acetylglucosamine deacetylation decreases autolysis in Lactococcus lactis.},
  author={Mickael Meyrand and A{\"i}da Boughammoura and Pascal Courtin and Christine M{\'e}zange and Alain Guillot and Marie-Pierre Chapot-Chartier},
  journal={Microbiology},
  year={2007},
  volume={153 Pt 10},
  pages={3275-85}
}
The gene xynD (renamed pgdA) of Lactococcus lactis IL1403 was shown to encode a peptidoglycan N-acetylglucosamine deacetylase. Inactivation of pgdA in L. lactis led to fully acetylated peptidoglycan, whereas cloning of pgdA on a multicopy plasmid vector resulted in an increased degree of peptidoglycan deacetylation, as shown by analysis of peptidoglycan constituent muropeptides. An increased amount of N-unsubstituted glucosamine residues in peptidoglycan resulted in a reduction of the rate of… CONTINUE READING

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