Peptidoglycan Crosslinking Relaxation Promotes Helicobacter pylori's Helical Shape and Stomach Colonization

@article{Sycuro2010PeptidoglycanCR,
  title={Peptidoglycan Crosslinking Relaxation Promotes Helicobacter pylori's Helical Shape and Stomach Colonization},
  author={Laura K. Sycuro and Zachary Pincus and Kimberley D. Gutierrez and Jacob Biboy and Chelsea A. Stern and Waldemar Vollmer and Nina R Salama},
  journal={Cell},
  year={2010},
  volume={141},
  pages={822-833}
}
The mechanisms by which bacterial cells generate helical cell shape and its functional role are poorly understood. Helical shape of the human pathogen Helicobacter pylori may facilitate penetration of the thick gastric mucus where it replicates. We identified four genes required for helical shape: three LytM peptidoglycan endopeptidase homologs (csd1-3) and a ccmA homolog. Surrounding the cytoplasmic membrane of most bacteria, the peptidoglycan (murein) sacculus is a meshwork of glycan strands… CONTINUE READING
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