Peptidic targeting of phosphatidylserine for the MRI detection of apoptosis in atherosclerotic plaques.

@article{Burtea2009PeptidicTO,
  title={Peptidic targeting of phosphatidylserine for the MRI detection of apoptosis in atherosclerotic plaques.},
  author={Carmen Burtea and Sophie Laurent and Eric Lancelot and S{\'e}bastien Ballet and Oltea Murariu and Olivier Rousseaux and Marc Port and Luce Vander Elst and Claire A Corot and Robert Nathan Muller},
  journal={Molecular pharmaceutics},
  year={2009},
  volume={6 6},
  pages={1903-19}
}
Molecular and cellular imaging of atherosclerosis has garnered more interest at the beginning of the 21st century, with aims to image in vivo biological properties of plaque lesions. Apoptosis seems an attractive target for the diagnosis of vulnerable atherosclerotic plaques prone to a thrombotic event. The aim of the present work was to screen for apoptosis peptide binders by phage display with the final purpose to detect apoptotic cells in atherosclerotic plaques by magnetic resonance imaging… CONTINUE READING