Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons.

@article{Zheng2003PeptidesTR,
  title={Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons.},
  author={Huiyuan Zheng and Michele M Corkern and Irina Ivanova Stoyanova and Laurel M. Patterson and Rui Tian and H. -R. Berthoud},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2003},
  volume={284 6},
  pages={R1436-44}
}
Corticolimbic circuits involving the prefrontal cortex, amygdala, and ventral striatum determine the reward value of food and might play a role in environmentally induced obesity. Chemical manipulation of the nucleus accumbens shell (AcbSh) has been shown to elicit robust feeding and Fos expression in the hypothalamus and other brain areas of satiated rats. To determine the neurochemical phenotype of hypothalamic neurons receiving input from the AcbSh, we carried out c-Fos/peptide double… CONTINUE READING
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