Peptides targeting Toll-like receptor signalling pathways for novel immune therapeutics.

  title={Peptides targeting Toll-like receptor signalling pathways for novel immune therapeutics.},
  author={Rosa P Gomariz and Irene Guti{\'e}rrez-Ca{\~n}as and Alicia Arranz and M Olivera Carri{\'o}n and Yasmina Juarranz and Javier Leceta and Carmen Mart{\'i}nez},
  journal={Current pharmaceutical design},
  volume={16 9},
Toll-like receptors (TLRs) are a family of key proteins that permit mammals to detect microbes and endogenous molecules, which are present in body fluids, cell membranes and cytoplasm. They confer mechanisms to the host for maintaining homeostasis, activating innate immunity and inducing signals that lead to the activation of adaptive immunity. TLR signalling induces the expression of pro-inflammatory and anti-viral genes through different and intricate pathways. However, persistent signalling… CONTINUE READING


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