Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion.

@article{Zou2005PeptidesST,
  title={Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion.},
  author={Jun Zou and Vladislav V. Glinsky and Linda A. Landon and Leslie J Matthews and Susan L. Deutscher},
  journal={Carcinogenesis},
  year={2005},
  volume={26 2},
  pages={309-18}
}
Intravascular cancer cell adhesion plays a significant role in the metastatic process. Studies indicate that galectin-3, a member of the galectin family of soluble animal lectins, is involved in carbohydrate-mediated metastatic cell heterotypic (between carcinoma cells and endothelium) and homotypic (between carcinoma cells) adhesion via interactions with the tumor-specific Thomsen-Friedenreich glycoantigen (TFAg). We hypothesized that blocking the galectin-3 carbohydrate recognition domain… CONTINUE READING

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