Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human.

@article{Plonquet2003PeptidesDF,
  title={Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human.},
  author={Anne Plonquet and Francisco Garcia-Pons and Eric Fernandez and Caramelle Philippe and J. W. Marquet and H{\'e}l{\`e}ne Rouard and Marie H{\'e}l{\`e}ne Delfau-Larue and Konstantinos Kosmatopoulos and François A. Lemonnier and Jean Pierre Farcet and Romain Kroum Gherardi and Pierre Langlade-Demoyen},
  journal={Journal of neuroimmunology},
  year={2003},
  volume={142 1-2},
  pages={93-100}
}
Anti-Hu syndrome is a paraneoplastic neurologic disease seemingly associated with an efficient antitumoral immune response against HuD protein expressed by both small cell lung cancer (SCLC) and neurons. Since anti-Hu antibodies are not pathogenic, and oligoclonal CD8(+) T cells infiltrate neoplastic and nervous tissues, we examined MHC class I-restricted immunogenicity of human HuD. Among 14 HuD-derived peptides potentially immunogenic in HLA-A*0201 restriction, 10 had actual in vitro binding… CONTINUE READING

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