Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human.

Abstract

Anti-Hu syndrome is a paraneoplastic neurologic disease seemingly associated with an efficient antitumoral immune response against HuD protein expressed by both small cell lung cancer (SCLC) and neurons. Since anti-Hu antibodies are not pathogenic, and oligoclonal CD8(+) T cells infiltrate neoplastic and nervous tissues, we examined MHC class I-restricted immunogenicity of human HuD. Among 14 HuD-derived peptides potentially immunogenic in HLA-A*0201 restriction, 10 had actual in vitro binding capacity to the HLA molecule, 8 elicited specific cytotoxic T lymphocytes (CTLs) in a humanized murine model after peptidic vaccination, 2 also elicited specific CTLs in healthy humans, and 1 was naturally processed and presented to the immune system.

Statistics

0200400600'04'05'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

861 Citations

Semantic Scholar estimates that this publication has 861 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Plonquet2003PeptidesDF, title={Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human.}, author={Anne Plonquet and Francisco Garcia-Pons and Eric Fernandez and Caramelle Philippe and Jeanine Marquet and H{\'e}l{\`e}ne Rouard and Marie H{\'e}l{\`e}ne Delfau-Larue and Konstantinos Kosmatopoulos and François A. Lemonnier and Jean Pierre Farcet and Romain Kroum Gherardi and Pierre Langlade-Demoyen}, journal={Journal of neuroimmunology}, year={2003}, volume={142 1-2}, pages={93-100} }