Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection.

@article{Wild1994PeptidesCT,
  title={Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection.},
  author={Carl T. Wild and Diane C. Shugars and Tammy Greenwell and Charlene B. McDanal and Thomas J. Matthews},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 21},
  pages={
          9770-4
        }
}
To define the role of the human immunodeficiency virus type 1 (HIV-1) envelope proteins in virus infection, a series of peptides were synthesized based on various regions of the HIV-1 transmembrane protein gp41. One of these peptides, DP-178, corresponding to a region predictive of alpha-helical secondary structure (residues 643-678 of the HIV-1LAI isolate), has been identified as a potent antiviral agent. This peptide consistently blocked 100% of virus-mediated cell-cell fusion at < 5 ng/ml… CONTINUE READING
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