Peptides containing dipropylglycine. Part 1. Preparation of protected derivatives of dipropylglycine and their incorporation into dipeptides.

Abstract

Methods for the incorporation of the hindered amino acid 2-amino-2-propylpentanoic acid (dipropylglycine, Dpg) into peptides have been investigated. Limitations on the preparation of protected derivatives of Dpg are discussed, and common methods of coupling examined. These methods are not subject to problems when used to link protein amino acids to the… (More)

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