Peptides come round: using SICLOPPS libraries for early stage drug discovery.

@article{Lennard2014PeptidesCR,
  title={Peptides come round: using SICLOPPS libraries for early stage drug discovery.},
  author={Katherine R Lennard and Ali Tavassoli},
  journal={Chemistry},
  year={2014},
  volume={20 34},
  pages={10608-14}
}
Cyclic peptides are an emerging class of molecular therapeutics that are increasingly viewed as ideal backbones for modulation of protein-protein interactions. A split-intein based method, termed SICLOPPS, enables the rapid generation of genetically encoded cyclic peptide libraries of around a hundred million members. Here we review recent approaches using SICLOPPS for the discovery of bioactive compounds. 

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