Peptides bound to major histocompatibility complex molecules.

  title={Peptides bound to major histocompatibility complex molecules.},
  author={Antonella Maffei and Paul Emerson Harris},
  volume={19 1},
Peptides are the means by which immune effector T cells recognize and defend against the foreign proteins of pathogens. T cell recognition of these molecules, however, is strictly dependent on peptide binding to the receptor-like molecules of the major histocompatibility complex (MHC) locus. The basic unit of recognition is a trimolecular complex consisting of the T cell antigen receptor, the MHC molecule, and the MHC-bound peptide ligand. The multistep process that culminates in MHC… CONTINUE READING