Peptides Constrained to Type VI beta-Turns. 1. Evidence for an Exceptionally Stable Intramolecular Hydrogen Bond.

@article{Kim1997PeptidesCT,
  title={Peptides Constrained to Type VI beta-Turns. 1. Evidence for an Exceptionally Stable Intramolecular Hydrogen Bond.},
  author={Kyonghee Kim and Juris P. Germanas},
  journal={The Journal of organic chemistry},
  year={1997},
  volume={62 9},
  pages={
          2847-2852
        }
}
The synthesis and conformational analysis of conjugates of amino acids with a type VI beta-turn dipeptide mimic (1) is described. The mimic possessed high structural similarity to the central two residues of the turn and was constrained from rotation about two of the four single bonds. Coupling of amino acids to the carboxyl group of the mimic afforded conjugates that were capable of forming intramolecular hydrogen bonds. In nonpolar solvents, IR and NMR spectra of the conjugates indicated that… CONTINUE READING
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