Peptidergic modulation of the membrane potential of the Schwann cell of the squid giant nerve fibre.

@article{Evans1986PeptidergicMO,
  title={Peptidergic modulation of the membrane potential of the Schwann cell of the squid giant nerve fibre.},
  author={Peter D. Evans and V F Reale and Jorge Villegas},
  journal={The Journal of physiology},
  year={1986},
  volume={379},
  pages={61-82}
}
The effects of a range of neuropeptides were investigated on the membrane potential of the Schwann cells of the giant nerve fibre of the tropical squid. Vasoactive intestinal peptide (VIP) produced a dose-dependent, long-lasting hyperpolarization of the Schwann-cell membrane potential. Among peptides structurally related to VIP, similar effects were produced by peptide histidine isoleucine (PHI) but not by secretin and glucagon. Substance P and somatostatin also hyperpolarized the Schwann-cell… CONTINUE READING

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