Peptidergic modulation of insect voltage-gated Ca(2+) currents: role of resting Ca(2+) current and protein kinases A and C.

@article{Wicher2001PeptidergicMO,
  title={Peptidergic modulation of insect voltage-gated Ca(2+) currents: role of resting Ca(2+) current and protein kinases A and C.},
  author={Dieter Wicher},
  journal={Journal of neurophysiology},
  year={2001},
  volume={86 5},
  pages={2353-62}
}
The modulation of voltage-gated Ca(2+) currents in isolated dorsal unpaired median (DUM) neurons of cockroach was investigated using whole cell patch clamp. The neuropeptide neurohormone D (NHD), a member of the adipokinetic hormone family, affected Ca(2+) currents at pico- to nanomolar concentrations. It strongly enhanced currents activating at lower depolarizations, whereas those activating at strong depolarizations were slightly attenuated. The first effect results from upregulation of a… CONTINUE READING

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