Peptide variants reveal how antibodies recognize major histocompatibility complex class I.

@article{Hogquist1993PeptideVR,
  title={Peptide variants reveal how antibodies recognize major histocompatibility complex class I.},
  author={Kristin A Hogquist and Andres G Grandea and Michael John Bevan},
  journal={European journal of immunology},
  year={1993},
  volume={23 11},
  pages={3028-36}
}
The T cell receptor (TcR) on CD8+ T lymphocytes recognizes a complex which consists of a major histocompatibility complex (MHC) heavy chain, beta 2-microglobulin (beta 2M), and peptide on the surface of antigen-presenting cells. Mutational analyses have suggested that the TcR recognizes both the alpha 1 and alpha 2 domains of the heavy chain as well as the peptide. In light of this, it is of interest to know to what extent the heavy chain domains take on distinct conformations when bound to… CONTINUE READING
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