Peptide transport by the multidrug resistance pump.

  title={Peptide transport by the multidrug resistance pump.},
  author={R. C. Sharma and Sumiko Inoue and Joseph Roitelman and Robert T. Schimke and Robert D. Simoni},
  journal={The Journal of biological chemistry},
  volume={267 9},
The membrane P-glycoprotein (P170) is an ATP-hydrolyzing transmembrane pump, and elevated levels of P170, due to higher expression with or without amplification of the multidrug resistance gene (mdr1), result in resistance to a variety of chemotherapeutic agents in mammalian cells. The function of the P170 pump has been proposed as a protection against toxic substances present in animal diets. Here we describe a Chinese hamster ovary cell line that was selected for resistance to a synthetic… CONTINUE READING

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