Peptide toxins that selectively target insect Na(V) and Ca(V) channels.

  title={Peptide toxins that selectively target insect Na(V) and Ca(V) channels.},
  author={Glenn F. King and Pierre Escoubas and Graham M. Nicholson},
  volume={2 2},
Numerous metazoans express venoms for the purpose of defense, competitor deterrence or prey capture. Peptide neurotoxins are particularly well represented in the venoms of arachnids, cnidarians and mollusks and these toxins often possess high affinity and specificity for particular classes of ion channels. Some of these toxins have become the defining pharmacology for certain vertebrate ion channel subtypes. Unfortunately, due to differences in the structure, pharmacology and ion selectivity of… CONTINUE READING


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