Peptide synthesis catalyzed by papain at alkaline pH values.

  title={Peptide synthesis catalyzed by papain at alkaline pH values.},
  author={Mitin YuV and N P Zapevalova and Gorbunova EYu},
  journal={International journal of peptide and protein research},
  volume={23 5},
The synthesis of peptides in the presence of papain at pH 8-9.5 is described. Starting substances are acylamino acid alkyl esters (the carboxyl component) and amides or tert.-butylesters of amino acids, as well as peptide (the amino component). Under such conditions secondary hydrolysis is not essential, making the synthesis of peptides soluble in aqueous medium. The yield of peptides is 50-94%. The effect of different factors (temperature, solvents, reagent concentrations) on the result of the… CONTINUE READING

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