Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

@article{Hammer2018PeptidespecificRO,
  title={Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells},
  author={Quirin Hammer and Timo R{\"u}ckert and Eva Maria Borst and Josefine Dunst and Andr{\'e} Haubner and Pawel Durek and Frederik Heinrich and Gilles Gasparoni and Marina Babi{\'c} and Adriana Tomic and Gabriella Pietra and Mikalai Nienen and Igor Wolfgang Blau and J{\"o}rg Hofmann and Il-Kang Na and Immo Prinz and Christian Koenecke and Philipp G. Hemmati and Nina Babel and Renate Arnold and J{\"o}rn Walter and Kevin Thurley and Mir-Farzin Mashreghi and Martin Messerle and Chiara Romagnani},
  journal={Nature Immunology},
  year={2018},
  volume={19},
  pages={453-463}
}
Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected with human cytomegalovirus (HCMV), an NK cell subset expressing the activating receptor NKG2C undergoes clonal-like expansion that partially resembles anti-viral adaptive responses. However, the viral ligand that drives the activation and differentiation of adaptive NKG2C+ NK cells has remained unclear. Here we found that adaptive NKG2C… 
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