Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

  title={Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells},
  author={Q. Hammer and T. R{\"u}ckert and E. Borst and J. Dunst and Andr{\'e} Haubner and P. Durek and F. Heinrich and G. Gasparoni and M. Babi{\'c} and Adriana Tomic and G. Pietra and M. Nienen and I. Blau and J. Hofmann and Il-Kang Na and I. Prinz and C. Koenecke and P. Hemmati and N. Babel and R. Arnold and J. Walter and K. Thurley and Mir-Farzin Mashreghi and M. Messerle and C. Romagnani},
  journal={Nature Immunology},
  • Q. Hammer, T. Rückert, +22 authors C. Romagnani
  • Published 2018
  • Biology, Medicine
  • Nature Immunology
  • Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected with human cytomegalovirus (HCMV), an NK cell subset expressing the activating receptor NKG2C undergoes clonal-like expansion that partially resembles anti-viral adaptive responses. However, the viral ligand that drives the activation and differentiation of adaptive NKG2C+ NK cells has remained unclear. Here we found that adaptive NKG2C… CONTINUE READING
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