Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

  title={Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells},
  author={Quirin Hammer and Timo R{\"u}ckert and Eva Maria Borst and Josefine Dunst and Andr{\'e} Haubner and Pawel Durek and Frederik Heinrich and Gilles Gasparoni and Marina Babi{\'c} and Adriana Tomic and Gabriella Pietra and Mikalai Nienen and Igor Wolfgang Blau and J{\"o}rg Hofmann and Il-Kang Na and Immo Prinz and Christian Koenecke and Philipp G. Hemmati and Nina Babel and Renate Arnold and J{\"o}rn Walter and Kevin Thurley and Mir-Farzin Mashreghi and Martin Messerle and Chiara Romagnani},
  journal={Nature Immunology},
Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged receptors, a hallmark of adaptive lymphocytes. In some people infected with human cytomegalovirus (HCMV), an NK cell subset expressing the activating receptor NKG2C undergoes clonal-like expansion that partially resembles anti-viral adaptive responses. However, the viral ligand that drives the activation and differentiation of adaptive NKG2C+ NK cells has remained unclear. Here we found that adaptive NKG2C… 

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The Direct Influence of Cytomegalovirus Lysate on the Natural Killer Cell Receptor Repertoire.

CMV may drive a direct influence on NK cell receptor repertoire, including the expansion of NK cells expressing NKG2C receptor, which is needed for further studies.

Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection

The preferential expansion of a unique subset of NK cells coexpressing the activating CD94–NKG2C receptor and CD57 in CMV+ donors is demonstrated and it is proposed that CD57 might provide a marker of “memory” NK cells that have been expanded in response to infection.

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.

The results provide new insight into the diversity of KIR repertoire and its adaptation to virus infection, suggesting a role for both activating and inhibitory KIRs in immunity to CMV infection.

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Cytomegalovirus-Infected Primary Endothelial Cells Trigger NKG2C+ Natural Killer Cells

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